Zocor
Product Information
Zocor, the brand drug for the generic name Simvastatin is a statin or
cholesterol- lowering medicine. It is an HMG CoA reductase inhibitor which
works by blocking the production of cholesterol by the liver. Besides
lowering the overall blood cholesterol, Zocor especially helps in lowering
the LDL 'bad' cholesterol levels, triglycerides, and apolipoprotein B
(a protein facilitating cholesterol production) in your blood. Zocor has
also proved to be helpful in increasing the level of HDL 'good' cholesterol
in your blood.
LDL cholesterol is primarily responsible
for the development of coronary artery disease. Thereby, lowering LDL
cholesterol levels retards progression and may even reverse coronary artery
disease. This function of Zocor is also beneficial in reducing the risk
of hardening of the arteries, which can lead to heart attacks, stroke,
and peripheral vascular disease.
Drug Class - Statins
Brand Name - Zocor
How to Use
- Take Zocor exactly as prescribed and directed by your doctor.
- Take each dose with a glass of water; and for maximum effect, Zocor
is usually taken at bedtime or with an evening meal.
- Monitor your blood cholesterol levels and liver function at regular
intervals so that the doctor can change your dosage if necessary.
- For best effect, eat low-fat, low cholesterol diet when the treatment
is in progress with Zocor.
- Grapefruit and grapefruit juice may interact with Zocor causing potentially
hazardous effects. Therefore, consult your doctor about including grapefruit
in your diet if you are using Zocor.
- Once treatment is initiated with Zocor, take the doses regularly
and do not stop taking the drug without consulting your doctor.
Side Effects
The Initial Adjustment: As your body adjusts to the medication,
you may have some side effects for first few days
- Gas
- Nausea
- Stomach Upset
- Heartburn
- Abdominal Pain
- Constipation or diarrhea
- Cough
- Headache
- Insomnia
Consult a Doctor
Consult your doctor if these effects persist or you experience an allergic
reaction (difficulty breathing; closing of the throat; swelling of the
lips, tongue, or face; or hives); blurred vision and decreased urine or
rust-colored urine.
Contact your doctor in eventualities of irrelevant muscle pain, tenderness,
or weakness; especially if accompanied by a fever or flu-like symptoms
or yellowing of the skin or eyes, abdominal pain, unnecessary fatigue,
dark colored urine or pale colored stools. These may be early symptoms
of muscle or liver problems arising out of Zocor use.
Drug Interaction
- Use Zocor after judging all possibilities of drug interaction.
- Consult your doctor and inform about all the prescription and nonprescription
drugs you use including vitamins, minerals, and herbal products.
- Zocor interacts with antifungal medications such as itraconazole
(Sporanox), fluconazole (Diflucan), or ketoconazole (Nizoral);
- It also interacts with protease inhibitor such as amprenavir (Agenerase),
indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir
(Kaletra), or saquinavir (Invirase, Fortovase);
- Zocor should not be taken if you are using drugs such as
- Cyclosporine (Sandimmune, Neoral);
- Erythromycin (E-Mycin, E.E.S., Ery-Tab, others) or clarithromycin
(Biaxin)
- Niacin (Nicolar, Nicobid, Slo-Niacin, others
- Gemfibrozil (Lopid), clofibrate (Atromid-S), or fenofibrate (Tricor)
- Digoxin (Lanoxin, Lanoxicaps)
- Cholestyramine (Questran) or colestipol (Colestid)
Precautions
- Precautions should be taken to guard against harmful side-effects
if you are suffering from liver disease. Inform your doctor in such
cases.
- Avoid or limit the use of alcohol while taking Zocor; as alcohol
may spur unwanted side effects.
- This drug is not recommended for use in children.
- Zocor has been included in the FDA pregnancy category X which means
that the drug is known to cause birth defects in an unborn child. So
it is recommended that you should not take Zocor if you are pregnant
or planning pregnancy.
- Zocor should also not be used by lactating mother as there are chances
that the drug may pass on to the breast milk.
Dosage
- The usual starting dose of Zocor is 40 milligrams once a day in the
evening or as prescribed by the doctor. The dosage can be adjusted every
4 weeks.
- Patients with severe, hereditary high cholesterol may be prescribed
as much as 80 milligrams a day, taken in doses of 20, 20, and 40 milligrams,
along with other treatments.
- Those suffering from kidney disease are usually recommended to start
off with an initial dose of 5 milligrams per day.
- Zocor is strictly advised to be used only under medical supervision
so as to prevent probable drug interaction and possible side-effects.
- The dosage for the drug varies from person to person depending upon
the body metabolism.
Overdose
Seek emergency medical attention immediately. Symptoms of a Zocor overdose
include nausea, diarrhea, stomach distress, and indigestion.
Missed Dose
Take the missed dose as soon as you remember. However, if it is too late
or almost time for your next dose, skip the missed dose and take only
your next regularly scheduled dose. Never take a double dose of this medication.
Storage
Zocor should be stored at room temperature in a cool and dry place. Keep
away from the reach of children.
Important Note
The following information is intended to supplement and not substitute
for, the expertise and judgment of your physician, pharmacist or other
healthcare professional. It should not be interpreted to indicate that
use of the drug is safe, apt, or effectual for you. It is recommended
that you consult your healthcare provider before using this drug.
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